CHR 6494 trifluoroacetate

Name: CHR 6494 trifluoroacetate
Brand: Tocris Bioscience
SKU: 5326

Tocris Bioscience, part of Bio-Techne | Catalog # 5326

COA / SDS

Potent and selective haspin inhibitor

Key Product Details

Description:	Potent and selective haspin inhibitor
Chemical Name:	3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	406.36

View Full Technical Details for CHR 6494 trifluoroacetate

Technical Data
Citations

Biological Activity for CHR 6494 trifluoroacetate

CHR 6494 trifluoroacetate is a potent and selective haspin kinase inhibitor (IC₅₀ = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G₂/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.

Compound Libraries for CHR 6494 trifluoroacetate

CHR 6494 trifluoroacetate is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CHR 6494 trifluoroacetate

M. Wt	406.36
Formula	C₁₆H₁₆N₆.CF₃CO₂H
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1458630-17-5
PubChem ID	91691123
InChi Key	ILWYDZNXJQESDI-UHFFFAOYSA-N
Smiles	CCCNC2=NN1C(C3=CC(C=NN4)=C4C=C3)=CN=C1C=C2.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHR 6494 trifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.64	100

Preparing Stock Solutions for CHR 6494 trifluoroacetate

The following data is based on the product molecular weight 406.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CHR 6494 trifluoroacetate

References are publications that support the biological activity of the product.

Huertas Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 2012 PMID: 21804608