CHIR 99021 trihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4953
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
Key Product Details
Description
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
Alternative Names
CT99021
Product Description
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.CHIR 99021, CHIR 99021 in solution and CHIR 99021 synthesized to cGMP guidelines also available.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
574.72
Formula
C22H18Cl2N8.3HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
CAS Number
1782235-14-6
PubChem ID
78243722
InChI Key
DSFVSCNMMZRCIA-UHFFFAOYSA-N
SMILES
ClC(C=C3Cl)=CC=C3C1=NC(NCCNC4=CC=C(C#N)C=N4)=NC=C1C2=NC(C)=CN2.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.37 | 25 | |
| DMSO | 28.74 | 50 |
Preparing Stock Solutions
for CHIR 99021 trihydrochloride
The following data is based on the product molecular weight 574.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.48 mL | 17.40 mL | 34.80 mL |
| 2.5 mM | 0.70 mL | 3.48 mL | 6.96 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ring Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 2003 PMID: 12606497
- Ye Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 2012 PMID: 22540008
- Pan AKT kinase activity is required for Li to modulate mood-related behaviors in mice. Neuropsychopharmacology 2011 PMID: 21389981
Product Specific Notices for CHIR 99021 trihydrochloride
For research use only
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