CHDI 00580985

Name: CHDI 00580985
Brand: Tocris Bioscience
SKU: 7881

Tocris Bioscience, part of Bio-Techne | Catalog # 7881

COA / SDS

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

Key Product Details

Description:	Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant
Chemical Name:	(2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	372.44

View Full Technical Details for CHDI 00580985

Technical Data
Citations

Biological Activity for CHDI 00580985

CHDI 00580985 is a potent and selective ROCK inhibitor (IC₅₀ values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC₅₀ = 4 nM). In vivo, CHDI 00580985 reduces ROCK signaling in Huntington's disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00580985

M. Wt	372.44
Formula	C₂₀H₂₅FN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2573071-18-6
PubChem ID	155749520
InChi Key	CIPXFTLGPVQJKN-HUUCEWRRSA-N
Smiles	FC1=CN=CC=C1N2C[C@H](N(CC2)C(N[C@@H](C3=CC(OC)=CC=C3)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHDI 00580985

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.24	100
	ethanol	37.24	100

Preparing Stock Solutions for CHDI 00580985

The following data is based on the product molecular weight 372.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.85 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for CHDI 00580985

References are publications that support the biological activity of the product.

Ladduwahetty Identification of a potent, selective, and brain-penetrant Rho kinase inhibitor and its activity in a mouse model of Huntington's disease. J.Med.Chem. 2022 PMID: 35816678