CHDI 00484077
Tocris Bioscience, part of Bio-Techne | Catalog # 7879
Potent and selective HDAC class IIa inhibitor
Key Product Details
Description
Potent and selective HDAC class IIa inhibitor
Product Description
CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC50 values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.Licensing Information
Sold under license from CHDI FoundationProduct Specifications
Molecular Weight
382.39
Formula
C18H21F3N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
CAS Number
3025894-92-9
PubChem ID
162675553
InChI Key
DBWSFWPXCPNWRZ-NEPJUHHUSA-N
SMILES
O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.24 | 100 with gentle warming | |
| Ethanol | 38.24 | 100 with gentle warming |
Preparing Stock Solutions
for CHDI 00484077
The following data is based on the product molecular weight 382.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.08 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stott Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 2021 PMID: 33738065
Product Specific Notices for CHDI 00484077
For research use only
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