CGP 55845 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1248

Potent and selective GABAB antagonist
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Key Product Details

Description

Potent and selective GABAB antagonist

View all GABA-B Receptor Antagonists »

Product Description

CGP 55845 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Inhibits GABAB responses to baclofen (IC50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro.

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications

Molecular Weight

438.71

Formula

C18H22Cl2NO3P.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride

CAS Number

149184-22-5

PubChem ID

5311042

InChI Key

ZODSPDOOCZZEIM-BBRMVZONSA-N

SMILES

Cl.C[C@H](NC[C@H](O)CP(O)(=O)CC1=CC=CC=C1)C1=CC=C(Cl)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.87 100 with gentle warming

Preparing Stock Solutions for CGP 55845 hydrochloride

The following data is based on the product molecular weight 438.71

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.40 mL 22.79 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CGP 55845 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 55845 hydrochloride

For research use only

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