CGP 52411
Tocris Bioscience, part of Bio-Techne | Catalog # 3360
EGFR inhibitor. Also inhibits Aβ42 fibril formation
Discontinued Product
3360 has been discontinued.
View all EGF Receptor Inhibitors products.
Key Product Details
Description
EGFR inhibitor. Also inhibits Aβ42 fibril formation
Alternative Names
DAPH
Product Description
CGP 52411 is a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.Product Specifications
Molecular Weight
329.35
Formula
C20H15N3O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
CAS Number
145915-58-8
PubChem ID
1697
InChI Key
AAALVYBICLMAMA-UHFFFAOYSA-N
SMILES
O=C2NC(C1=CC(NC4=CC=CC=C4)=C(NC3=CC=CC=C3)C=C12)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.94 | 100 | |
| Ethanol | 8.23 | 25 |
Preparing Stock Solutions
for CGP 52411
The following data is based on the product molecular weight 329.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.18 mL | 30.36 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.07 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Blanchard Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 2004 PMID: 15388848
- Wang Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 2008 PMID: 18480256
- Buchdunger 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 1994 PMID: 8134396
Product Specific Notices for CGP 52411
For research use only
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