CGI 1746
Tocris Bioscience, part of Bio-Techne | Catalog # 6965
Potent, reversible BTK inhibitor
Key Product Details
Description
Potent, reversible BTK inhibitor
Product Description
CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).Product Specifications
Molecular Weight
579.70
Formula
C34H37N5O4
Storage
Store at -20°C
Purity
≥97%
Chemical Name
N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
CAS Number
910232-84-7
PubChem ID
24857323
InChI Key
JIFCFQDXHMUPGP-UHFFFAOYSA-N
SMILES
CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N2CCOCC2)C1=O)C1=C(C)C(NC(=O)C2=CC=C(C=C2)C(C)(C)C)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.9 | 5 | |
| Ethanol | 11.59 | 20 |
Preparing Stock Solutions
for CGI 1746
The following data is based on the product molecular weight 579.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.63 mL | 43.13 mL | 86.25 mL |
| 1 mM | 1.73 mL | 8.63 mL | 17.25 mL |
| 2 mM | 0.86 mL | 4.31 mL | 8.63 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kokabee Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol. Ther. 2015 PMID: 26383180
- Di Paolo Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 2011 PMID: 21113169
Product Specific Notices for CGI 1746
For research use only
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