Cetrorelix acetate

Name: Cetrorelix acetate
Brand: Tocris Bioscience
SKU: 8821

Tocris Bioscience, part of Bio-Techne | Catalog # 8821

COA / SDS

Potent GnRH receptor antagonist

Key Product Details

Description:	Potent GnRH receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1431.06

View Full Technical Details for Cetrorelix acetate

Technical Data
Citations

Biological Activity for Cetrorelix acetate

Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (K_D = 0.202 nM, IC₅₀ = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

Technical Data for Cetrorelix acetate

M. Wt	1431.06
Formula	C₇₀H₉₂ClN₁₇O₁₄
Single Letter Sequence	XFXSYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = 4-Cl-D-Phe, X-3 = 3-(3-Pyridyl)-D-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	145672-81-7
PubChem ID	25074887
InChi Key	SBNPWPIBESPSIF-MHWMIDJBSA-N
Smiles	CC(C[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(N)=O)C)=O)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)CO)=O)CC6=CC=C(C=C6)O)=O)CCCNC(N)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cetrorelix acetate

Solubility

Soluble to 1mg/ml in 0.02 M acetic acid

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References for Cetrorelix acetate

References are publications that support the biological activity of the product.

Gründker and Emons Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 2003 PMID: 14594454
Telegdy Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 2009 PMID: 19375162
Beckers Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 1997 PMID: 9300077