CD 3254
Tocris Bioscience, part of Bio-Techne | Catalog # 3302
Potent and selective RXRα agonist
Key Product Details
Description
Potent and selective RXRα agonist
Product Description
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. CD 3254 can promote chemical reprogramming of mouse fibroblasts. In a fast chemical reprogramming protocol, it promotes reprogramming of foetal mouse dorsal fibroblasts (MDFs) and adult mouse lung fibroblasts (MLFs) to iPS cells within 12 days.Product Specifications
Molecular Weight
364.48
Formula
C24H28O3
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
CAS Number
196961-43-0
PubChem ID
44566110
InChI Key
DYLLZSVPAUUSSB-VQHVLOKHSA-N
SMILES
CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(C)=C2)C(C)(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.45 | 100 | |
| Ethanol | 36.45 | 100 |
Preparing Stock Solutions
for CD 3254
The following data is based on the product molecular weight 364.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen A fast chemical reprogramming system promotes cell identity transition through a diapause-like state. Nat.Cell Biol. 2023 PMID: 37550515
- Jin Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception. Proc.Natl.Acad.Sci. 2023 PMID: 37192170
- le Maire Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO.Rep. 2009 PMID: 19270714
- Nahoum Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 2007 PMID: 17947383
- Pogenberg Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J.Biol.Chem. 2005 PMID: 15528208
Product Specific Notices for CD 3254
For research use only
Loading...
Loading...