CBA

Name: CBA
Brand: Tocris Bioscience
SKU: 6724

Tocris Bioscience, part of Bio-Techne | Catalog # 6724

Citations (5)

COA / SDS

Selective TRPM4 blocker

Key Product Details

Description:	Selective TRPM4 blocker
Chemical Name:	4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	340.16

View Full Technical Details for CBA

Technical Data
Citations

Biological Activity for CBA

CBA is a selective TRPM4 blocker (IC₅₀ = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.

Compound Libraries for CBA

CBA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CBA

M. Wt	340.16
Formula	C₁₅H₁₁Cl₂NO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	351424-20-9
PubChem ID	2264067
InChi Key	CVQCJPCMPGKEDH-UHFFFAOYSA-N
Smiles	OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CBA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.01	50

Preparing Stock Solutions for CBA

The following data is based on the product molecular weight 340.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.88 mL	29.40 mL	58.80 mL
2.5 mM	1.18 mL	5.88 mL	11.76 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
25 mM	0.12 mL	0.59 mL	1.18 mL

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References for CBA

References are publications that support the biological activity of the product.

Ozhathil Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 2018 PMID: 29579323
Bianchi The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 2018 PMID: 29996905

CBA