CB 13
Tocris Bioscience, part of Bio-Techne | Catalog # 2928
Potent dual CB1/CB2 agonist
Discontinued Product
2928 has been discontinued.
View all Non-selective Cannabinoid Receptor Agonists products.
Key Product Details
Description
Potent dual CB1/CB2 agonist
Product Description
CB 13 is a potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.Product Specifications
Molecular Weight
368.47
Formula
C26H24O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
CAS Number
432047-72-8
PubChem ID
9799417
InChI Key
RSUMDJRTAFBISX-UHFFFAOYSA-N
SMILES
O=C(C3=CC=CC4=C3C=CC=C4)C2=CC=C(OCCCCC)C1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.85 | 100 | |
| Ethanol | 18.42 | 50 |
Preparing Stock Solutions
for CB 13
The following data is based on the product molecular weight 368.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.71 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cluny Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J.Pharmacol.Exp.Ther. 2010 PMID: 20571060
- Dziadulewicz Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J.Med.Chem. 2007 PMID: 17630726
Product Specific Notices for CB 13
For research use only
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