Caspase-1/ICE Inhibitor Z-WEHD-FMK
R&D Systems, part of Bio-Techne | Catalog # FMK002
Key Product Details
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
Conjugate
Unconjugated
Formulation, Preparation and Storage
FMK002
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
Background: Caspase-1
Caspase-1, also known as IL-1 beta-converting enzyme (ICE), is an aspartic protease that plays a key role in the inflammatory response and apoptosis. Caspase-1 precursor (about 50kDa) can be cleaved and the active enzyme consists of a complex of two 20 kDa and two 10 kDa subunits which associate following cleavage of inactive precursors. Caspase-1 is required for proteolytic cleavage of the IL-1 beta precursor to form the active proinflammatory cytokine.
Additional Caspase-1 Products
Product Documents for Caspase-1/ICE Inhibitor Z-WEHD-FMK
Product Specific Notices for Caspase-1/ICE Inhibitor Z-WEHD-FMK
For research use only
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