Carvedilol

Tocris Bioscience, part of Bio-Techne | Catalog # 2685

Potent and non-selective β antagonist; also potent α1 antagonist
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Key Product Details

Description

Potent and non-selective β antagonist; also potent α1 antagonist

Alternative Names

BM 14190

View all Non-selective Adrenergic beta Receptor Antagonists »

Product Description

Carvedilol is a potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.

Product Specifications

Molecular Weight

406.47

Formula

C24H26N2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

CAS Number

72956-09-3

PubChem ID

2585

InChI Key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

SMILES

COC1=C(OCCNCC(O)COC2=CC=CC3=C2C2=C(N3)C=CC=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.64 100
Ethanol 20.32 50

Preparing Stock Solutions for Carvedilol

The following data is based on the product molecular weight 406.47

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.30 mL 24.60 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Carvedilol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Carvedilol

For research use only

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