Carbamazepine

Product Description

Carbamazepine is an inhibitor of neuronal voltage-gated Na⁺ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl^- currents in HEK 293 cells expressing the GABA_A receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.

Solubility

Preparing Stock Solutions for Carbamazepine

The following data is based on the product molecular weight 236.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. CNS Neurosci.Ther. 2018 PMID: 29656576
• Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
• Sarkar Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 2009 PMID: 18636076
• Lipkind and Fozzard Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 2010 PMID: 20643904
• Afanas'ev Lamotrigine and carbamaz. affect differently the release of D-[³H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 1999 PMID: 10485587
• Granger Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen. Mol.Pharmacol. 1995 PMID: 7603459