Calcitriol
Tocris Bioscience, part of Bio-Techne | Catalog # 2551
Vitamin D receptor (VDR) agonist
Key Product Details
Description
Vitamin D receptor (VDR) agonist
Alternative Names
1,25-Dihydroxyvitamin D3
Product Description
Calcitriol is an active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.Product Specifications
Molecular Weight
416.64
Formula
C27H44O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
CAS Number
32222-06-3
PubChem ID
5280453
InChI Key
GMRQFYUYWCNGIN-NKMMMXOESA-N
SMILES
C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.33 | 20 | |
| Ethanol | 2.08 | 5 |
Preparing Stock Solutions
for Calcitriol
The following data is based on the product molecular weight 416.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.00 mL | 60.00 mL | 120.01 mL |
| 1 mM | 2.40 mL | 12.00 mL | 24.00 mL |
| 2 mM | 1.20 mL | 6.00 mL | 12.00 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Beer and Myrthue Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 2004 PMID: 15026558
- Nijenhuis The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 2006 PMID: 16873882
- Canalejo The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 2000 PMID: 11004217
Product Specific Notices for Calcitriol
For research use only
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