Calcitriol

Name: Calcitriol
Brand: Tocris Bioscience
SKU: 2551

Tocris Bioscience, part of Bio-Techne | Catalog # 2551

Citations (39)

COA / SDS

Vitamin D receptor (VDR) agonist

Key Product Details

Description:	Vitamin D receptor (VDR) agonist
Alternative Names:	1,25-Dihydroxyvitamin D3
Chemical Name:	(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
Purity:	≥98% (HPLC)
Molecular Weight:	416.64

View Full Technical Details for Calcitriol

Technical Data
Citations

Biological Activity for Calcitriol

Calcitriol is an active metabolite of vitamin D₃ that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca²⁺ absorption and regulates bone Ca²⁺ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data for Calcitriol

M. Wt	416.64
Formula	C₂₇H₄₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	32222-06-3
PubChem ID	5280453
InChi Key	GMRQFYUYWCNGIN-NKMMMXOESA-N
Smiles	C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Calcitriol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	8.33	20
	ethanol	2.08	5

Preparing Stock Solutions for Calcitriol

The following data is based on the product molecular weight 416.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.00 mL	60.00 mL	120.01 mL
1 mM	2.40 mL	12.00 mL	24.00 mL
2 mM	1.20 mL	6.00 mL	12.00 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

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Reconstitution Calculator

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References for Calcitriol

References are publications that support the biological activity of the product.

Beer and Myrthue Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 2004 PMID: 15026558
Nijenhuis The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 2006 PMID: 16873882
Canalejo The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 2000 PMID: 11004217