Calcipotriol is a vitamin D₃ analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

Product Specifications

Molecular Weight

412.60

Formula

C₂₇H₄₀O₃

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol

CAS Number

112965-21-6

PubChem ID

5288783

InChI Key

LWQQLNNNIPYSNX-UROSTWAQSA-N

SMILES

[H][C@@]12[C@]([C@]([C@@H](/C=C/[C@@H](O)C4CC4)C)([H])CC2)(C)CCC/C1=C\C=C3/C([C@@H](O)C[C@H](O)C3)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.26	100
	Ethanol	41.26	100

Preparing Stock Solutions for Calcipotriol

The following data is based on the product molecular weight 412.60

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.12 mL	24.24 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Background References

References are publications that support the biological activity of the product.

Cunningham Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J.Clin.Invest. 2017 PMID: 27869649
Lovato Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J.Dermatol.Sci. 2016 PMID: 26794805
Knutson Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D₂ in rats. Biochem.Pharmacol. 1997 PMID: 9113104
Wietrzyk Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 2007 PMID: 17351397
Binderu Comparison of calcipotriol with selected metabolites and analogues of vitamin D₃: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 1993 PMID: 8396769

Calcipotriol

Tocris Bioscience, part of Bio-Techne | Catalog # 2700

Key Product Details

Description

Alternative Names

View all Additional VDR-like Receptor Compounds »

Product Description