Caffeic acid phenethyl ester

Name: Caffeic acid phenethyl ester
Brand: Tocris Bioscience
SKU: 2743

Tocris Bioscience, part of Bio-Techne | Catalog # 2743

Citations (49)

COA / SDS

Specific inhibitor of NF-κB activation

Key Product Details

Description:	Specific inhibitor of NF-κB activation
Alternative Names:	CAPE
Chemical Name:	3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	284.31

View Full Technical Details for Caffeic acid phenethyl ester

Technical Data
Citations

Biological Activity for Caffeic acid phenethyl ester

Caffeic acid phenethyl ester is an antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Technical Data for Caffeic acid phenethyl ester

M. Wt	284.31
Formula	C₁₇H₁₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	104594-70-9
PubChem ID	5281787
InChi Key	SWUARLUWKZWEBQ-VQHVLOKHSA-N
Smiles	OC1=C(O)C=C(/C=C/C(OCCC2=CC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Caffeic acid phenethyl ester

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.43	100
	ethanol	28.43	100

Preparing Stock Solutions for Caffeic acid phenethyl ester

The following data is based on the product molecular weight 284.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for Caffeic acid phenethyl ester

References are publications that support the biological activity of the product.

Fitzpatrick Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J.Pharmacol.Exp.Ther. 2001 PMID: 11714876
Natarajan Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA
Sud'ina Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 1993 PMID: 7689063