CAF 382

Product Description

CAF 382 is potent and selective CDKL5 (cyclin-dependent kinase-like 5) inhibitor (IC₅₀ = 10 nM). Exhibits nearly 100-fold selectivity for CDKL5 over CDKL2, low inhibition for CDKL3 and CDKL4 (IC₅₀ = 2.1-2.7 µM), and no inhibition for CDKL1. CAF 382 lacks GSK3β activity. It causes a significant reduction in pSer222 EB2 at 5 nM without a change in total EB2 levels in rat primary cortical neuron cultures. CAF 382 is an analog of SNS 032 (Cat. No. 4075).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC-CAF382-1 probe summary on the SGC website.

Solubility

Preparing Stock Solutions for CAF 382

The following data is based on the product molecular weight 480.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.41 mL	20.81 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Castano Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinaselike 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife 2023 PMID: 37490324