Caerulein

Name: Caerulein
Brand: Tocris Bioscience
SKU: 6264
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6264

(1)

Citations (12)

COA / SDS

CCK agonist

Key Product Details

Description:	CCK agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1352.4

View Full Technical Details for Caerulein

Technical Data
Citations / Reviews (1)

Biological Activity for Caerulein

Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.

Technical Data for Caerulein

M. Wt	1352.4
Formula	C₅₈H₇₃N₁₃O₂₁S₂
Single Letter Sequence	XQDYTGWMDF (Modifications: X = Glp, Tyr-4 = Tyr(SO₃H), Phe-10 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	17650-98-5
PubChem ID	16132921
InChi Key	YRALAIOMGQZKOW-UHFFFAOYSA-N
Smiles	CC(C(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Caerulein

Solubility

Soluble to 1mg/ml in water

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References for Caerulein

References are publications that support the biological activity of the product.

Furuyama Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 2016 PMID: 27244456
Pradel Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 1993 PMID: 7679894
Murakami Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 2017 PMID: 27546622