CaCCinh-A01

Name: CaCCinh-A01
Brand: Tocris Bioscience
SKU: 4877

Tocris Bioscience, part of Bio-Techne | Catalog # 4877

Citations (39)

COA / SDS

Calcium-activated chloride channel (CaCC) inhibitor

Key Product Details

Description:	Calcium-activated chloride channel (CaCC) inhibitor
Chemical Name:	6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	347.43

View Full Technical Details for CaCCinh-A01

Technical Data
Citations

Biological Activity for CaCCinh-A01

CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC₅₀ ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC₅₀ = 2.1 μM, in TMEM16A-expressing FRT cells).

Technical Data for CaCCinh-A01

M. Wt	347.43
Formula	C₁₈H₂₁NO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	407587-33-1
PubChem ID	2898877
InChi Key	ACLUEOBQFRYTQS-UHFFFAOYSA-N
Smiles	CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CaCCinh-A01

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.74	100
	ethanol	3.47	10 with gentle warming

Preparing Stock Solutions for CaCCinh-A01

The following data is based on the product molecular weight 347.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.88 mL	14.39 mL	28.78 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
10 mM	0.29 mL	1.44 mL	2.88 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for CaCCinh-A01

References are publications that support the biological activity of the product.

De La Fuente Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 2008 PMID: 18083779
Namkung TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 2011 PMID: 21084298