CA 074

Tocris Bioscience, part of Bio-Techne | Catalog # 4863

Selective cathepsin B inhibitor
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Key Product Details

Description

Selective cathepsin B inhibitor

View all Synthetic Cathepsin Inhibitors »

Product Description

CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Product Specifications

Molecular Weight

383.44

Formula

C18H29N3O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

CAS Number

134448-10-5

PubChem ID

9821383

InChI Key

ZEZGJKSEBRELAS-PEDHHIEDSA-N

SMILES

O=[C@](NCCC)[C@H]1O[C@@H]1[C@@](N[C@@H]([C@@H](C)CC)[C@](N2[C@H](C(O)=O)CCC2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 7.67 20

Preparing Stock Solutions for CA 074

The following data is based on the product molecular weight 383.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.04 mL 65.20 mL 130.40 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
2 mM 1.30 mL 6.52 mL 13.04 mL
10 mM 0.26 mL 1.30 mL 2.61 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for CA 074

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CA 074

For research use only

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