C-DIM 12

Tocris Bioscience, part of Bio-Techne | Catalog # 5821

Nurr1 activator; inhibits NF-κB-dependent gene expression
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Key Product Details

Description

Nurr1 activator; inhibits NF-κB-dependent gene expression

View all Nuclear Hormone Receptor 4A Activators »

Product Description

C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Product Specifications

Molecular Weight

356.85

Formula

C23H17ClN2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]

CAS Number

178946-89-9

PubChem ID

5302583

InChI Key

LTLRXTDMXOFBDW-UHFFFAOYSA-N

SMILES

ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.69 100
Ethanol 35.69 100

Preparing Stock Solutions for C-DIM 12

The following data is based on the product molecular weight 356.85

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.80 mL 14.01 mL 28.02 mL
5 mM 0.56 mL 2.80 mL 5.60 mL
10 mM 0.28 mL 1.40 mL 2.80 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Product Documents for C-DIM 12

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for C-DIM 12

For research use only

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