C 87

Name: C 87
Brand: Tocris Bioscience
SKU: 5484
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5484

(2)

Citations (8)

COA / SDS

TNF-α inhibitor

Discontinued Product

5484 has been discontinued. View all Cytokine Compounds products.

Key Product Details

Description:	TNF-α inhibitor
Chemical Name:	3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
Purity:	≥98% (HPLC)
Molecular Weight:	502.93

View Full Technical Details for C 87

Technical Data
Citations / Reviews (2)

Biological Activity for C 87

C 87 is a TNF-α inhibitor (K_d = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.

Technical Data for C 87

M. Wt	502.93
Formula	C₂₄H₁₅ClN₆O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	332420-90-3
PubChem ID	5756872
InChi Key	VELQTEBILFDDQX-SLMZUGIISA-N
Smiles	O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for C 87

References are publications that support the biological activity of the product.

Ma A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 2014 PMID: 24634219

C 87

Tocris Bioscience, part of Bio-Techne | Catalog # 5484

Key Product Details

Biological Activity for C 87

Technical Data for C 87

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for C 87

Product Documents for C 87

COA

Certificate of Analysis

SDS

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