C 021 dihydrochloride

Name: C 021 dihydrochloride
Brand: Tocris Bioscience
SKU: 3581
Rating: 1 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3581

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Citations (22)

COA / SDS

Potent CCR4 antagonist

Key Product Details

Description:	Potent CCR4 antagonist
Chemical Name:	2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	540.57

View Full Technical Details for C 021 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for C 021 dihydrochloride

C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC₅₀ values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Compound Libraries for C 021 dihydrochloride

C 021 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for C 021 dihydrochloride

M. Wt	540.57
Formula	C₂₇H₄₁N₅O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1784252-84-1
PubChem ID	56972238
InChi Key	GKJKNYQUFAPLOQ-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C(N=C(N4CCC(N5CCCCC5)CC4)N=C2NC3CCCCCC3)C2=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 021 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.96	50
	DMSO	53.93	100

Preparing Stock Solutions for C 021 dihydrochloride

The following data is based on the product molecular weight 540.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.50 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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Reconstitution Calculator

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References for C 021 dihydrochloride

References are publications that support the biological activity of the product.

Yokoyama Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 2009 PMID: 19081254