BX 471

Tocris Bioscience, part of Bio-Techne | Catalog # 3496

COA / SDS

Potent, selective CCR1 antagonist

Key Product Details

Description:	Potent, selective CCR1 antagonist
Alternative Names:	ZK-811752
Chemical Name:	(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine
Purity:	≥98% (HPLC)
Molecular Weight:	434.89

View Full Technical Details for BX 471

Technical Data
Citations

Biological Activity for BX 471

BX 471 is a potent, selective non-peptide CCR1 antagonist (K_i = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca²⁺ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Compound Libraries for BX 471

BX 471 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BX 471

M. Wt	434.89
Formula	C₂₁H₂₄ClFN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	217645-70-0
PubChem ID	512282
InChi Key	XQYASZNUFDVMFH-CQSZACIVSA-N
Smiles	FC1=CC=C(CN2C[C@@H](C)N(C(COC3=CC=C(Cl)C=C3NC(N)=O)=O)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BX 471

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.49	100
	ethanol	21.74	50

Preparing Stock Solutions for BX 471

The following data is based on the product molecular weight 434.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.50 mL	22.99 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for BX 471

References are publications that support the biological activity of the product.

Anders A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J.Clin.Invest. 2002 PMID: 11805137
Furuichi Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J.Immunol. 2008 PMID: 19050287
Liang Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J.Biol.Chem. 2000 PMID: 10748002