BX 471
Tocris Bioscience, part of Bio-Techne | Catalog # 3496
Potent, selective CCR1 antagonist
Key Product Details
Description
Potent, selective CCR1 antagonist
Alternative Names
ZK-811752
Product Description
BX 471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.Product Specifications
Molecular Weight
434.89
Formula
C21H24ClFN4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine
CAS Number
217645-70-0
PubChem ID
512282
InChI Key
XQYASZNUFDVMFH-CQSZACIVSA-N
SMILES
FC1=CC=C(CN2C[C@@H](C)N(C(COC3=CC=C(Cl)C=C3NC(N)=O)=O)CC2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.49 | 100 | |
| Ethanol | 21.74 | 50 |
Preparing Stock Solutions
for BX 471
The following data is based on the product molecular weight 434.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.50 mL | 22.99 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Anders A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J.Clin.Invest. 2002 PMID: 11805137
- Furuichi Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J.Immunol. 2008 PMID: 19050287
- Liang Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J.Biol.Chem. 2000 PMID: 10748002
Product Specific Notices for BX 471
For research use only
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