Bupropion hydrochloride

Name: Bupropion hydrochloride
Brand: Tocris Bioscience
SKU: 2831
Price: 175 USD

Catalog # 2831 | Tocris Bioscience a Bio-Techne Brand

Citations (4)

COA / SDS

Non-selective inhibitor of dopamine and noradrenalin transporters

Key Product Details

Description:	Non-selective inhibitor of dopamine and noradrenalin transporters
Chemical Name:	1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	276.2

View Full Technical Details for Bupropion hydrochloride

Biological Activity for Bupropion hydrochloride

Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (K_i values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Compound Libraries for Bupropion hydrochloride

Bupropion hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bupropion hydrochloride

M. Wt	276.2
Formula	C₁₃H₁₈ClNO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	31677-93-7
PubChem ID	62884
InChi Key	HEYVINCGKDONRU-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(C(C(C)NC(C)(C)C)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bupropion hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	27.62	100
	DMSO	27.62	100

Preparing Stock Solutions for Bupropion hydrochloride

The following data is based on the product molecular weight 276.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.10 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Bupropion hydrochloride

References are publications that support the biological activity of the product.

Dwoskin Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 2006 PMID: 17227286
Torres Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858
Slemmer Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 2000 PMID: 10991997

Citations for Bupropion hydrochloride (4)

Showing 1 - 4 of 4 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Bupropion hydrochloride include:

Durham et al. (2019) Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells. Sci Rep. 9:3805
PMID: 30846819
Czysz et al. (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Cardiovasc Res. 40:766
PMID: 25249058
Nunes et al. (2013) Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression. J Neurosci. 33:19120
PMID: 24305809
Li et al. (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Neuropsychopharmacology. 29:15551
PMID: 20007479

There are no citations that match your criteria.

Showing 1 - 4 of 4 citations Showing All

Product Documents for Bupropion hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.