BTS
Tocris Bioscience, part of Bio-Techne | Catalog # 1870
Selective inhibitor of skeletal muscle myosin II ATPase activity
Key Product Details
Description
Selective inhibitor of skeletal muscle myosin II ATPase activity
Product Description
BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.Product Specifications
Molecular Weight
261.34
Formula
C14H15NO2S
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-Methyl-N-(phenylmethyl)benzenesulfonamide
CAS Number
1576-37-0
PubChem ID
95801
InChI Key
WTHKAJZQYNKTCJ-UHFFFAOYSA-N
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NCC1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.13 | 100 | |
| Ethanol | 18.29 | 70 |
Preparing Stock Solutions
for BTS
The following data is based on the product molecular weight 261.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.13 mL | 38.26 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ramachandran Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 2003 PMID: 12673599
- Shaw Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 2003 PMID: 12755615
- Cheung A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 2001 PMID: 11744924
Product Specific Notices for BTS
For research use only
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