BTD
Tocris Bioscience, part of Bio-Techne | Catalog # 6940
Selective TRPC5 activator
Product Description
BTD is a selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.Product Specifications
Molecular Weight
459.61
Formula
C24H33N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide
CAS Number
896684-04-1
PubChem ID
46369355
InChI Key
YXADKMPRWFBOHW-UHFFFAOYSA-N
SMILES
CC1=CC=C2C(NC(CCC(=O)NCCCOC34CC5CC(CC(C5)C3)C4)=N[S]2(=O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.96 | 100 |
Preparing Stock Solutions
for BTD
The following data is based on the product molecular weight 459.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.88 mL | 21.76 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Beckmann A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 2017 PMID: 28807145
Product Specific Notices for BTD
For research use only
Loading...
Loading...