BRL 52537 hydrochloride

Name: BRL 52537 hydrochloride
Brand: Tocris Bioscience
SKU: 0699
Price: 172 USD

Catalog # 0699 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Potent and selective κ agonist

Key Product Details

Description:	Potent and selective κ agonist
Chemical Name:	(±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	391.77

View Full Technical Details for BRL 52537 hydrochloride

Biological Activity for BRL 52537 hydrochloride

The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 52537 hydrochloride

M. Wt	391.77
Formula	C₁₈H₂₄Cl₂N₂O.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	112282-24-3
PubChem ID	11315337
InChi Key	NGVLSOWJSUUYDE-UHFFFAOYSA-N
Smiles	Cl.ClC1=CC=C(CC(=O)N2CCCCC2CN2CCCC2)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 52537 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.96	5 with gentle warming

Preparing Stock Solutions for BRL 52537 hydrochloride

The following data is based on the product molecular weight 391.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	51.05 mL	255.25 mL	510.50 mL
0.25 mM	10.21 mL	51.05 mL	102.10 mL
0.5 mM	5.11 mL	25.53 mL	51.05 mL
2.5 mM	1.02 mL	5.11 mL	10.21 mL

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References for BRL 52537 hydrochloride

References are publications that support the biological activity of the product.

Vecchietti (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 1991 PMID: 1846921

Citations for BRL 52537 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for BRL 52537 hydrochloride include:

Morse et al. (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 14:17
PMID: 23497702

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Product Documents for BRL 52537 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.