BQ-3020

Tocris Bioscience, part of Bio-Techne | Catalog # 1189

COA / SDS

Selective ETB agonist

Key Product Details

Description:	Selective ET_B agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2006.35

View Full Technical Details for BQ-3020

Technical Data
Citations

Biological Activity for BQ-3020

BQ-3020 is a highly potent and selective ET_B endothelin receptor agonist (K_i values are 0.18 and 970 nM at human ET_B and ET_A receptors respectively).

Technical Data for BQ-3020

M. Wt	2006.35
Formula	C₉₆H₁₄₀N₂₀O₂₅S
Single Letter Sequence	LMDKEAVYFAHLDIIW (Modifications: Leu-1 = N-terminal Ac)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	143113-45-5
PubChem ID	16135850
InChi Key	AYJUXFCWNAVJLN-FHOIYVHLSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BQ-3020

Solubility

Soluble to 0.5mg/ml in sodium bicarbonate (0.03M)

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References for BQ-3020

References are publications that support the biological activity of the product.

Sakamoto Distinct subdomains of human endothelin receptors determine their selectivity to endothelin_A-selective antagonist and endothelin_B-selective agonists. J.Biol.Chem. 1993 PMID: 8473300
Ihara [₃H]-BQ-123, a highly specific and reversible radioligand for the endothelin ET_A receptor subtype. Eur.J.Pharmacol. 1995 PMID: 7768260
Reynolds Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 1995 PMID: 7733918
Ekelund Effects of selective ET_B-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 1994 PMID: 7921617