BPTES

Tocris Bioscience, part of Bio-Techne | Catalog # 5301

Selective allosteric glutaminase (GLS1) inhibitor
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Key Product Details

Description

Selective allosteric glutaminase (GLS1) inhibitor

View all Glutaminase Inhibitors »

Product Description

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

Product Specifications

Molecular Weight

524.68

Formula

C24H24N6O2S3

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

CAS Number

314045-39-1

PubChem ID

3372016

InChI Key

MDJIPXYRSZHCFS-UHFFFAOYSA-N

SMILES

O=C(NC2=NN=C(CCSCCC4=NN=C(S4)NC(CC3=CC=CC=C3)=O)S2)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.49 20

Preparing Stock Solutions for BPTES

The following data is based on the product molecular weight 524.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.53 mL 47.65 mL 95.30 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
2 mM 0.95 mL 4.76 mL 9.53 mL
10 mM 0.19 mL 0.95 mL 1.91 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for BPTES

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BPTES

For research use only

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