Bosentan
Tocris Bioscience, part of Bio-Techne | Catalog # 6232
High affinity dual ETA and ETB receptor antagonist;orally bioavailable
Key Product Details
Description
High affinity dual ETA and ETB receptor antagonist;orally bioavailable
Alternative Names
Ro 47-0203
Product Description
Bosentan is a high affinity dual ETA and ETB receptor antagonist (Ki values are 4.7 and 95 nM for ETA and ETB, respectively). Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of rat trachea in vitro. Orally bioavailable.Product Specifications
Molecular Weight
551.61
Formula
C27H29N5O6S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide
CAS Number
147536-97-8
PubChem ID
104865
InChI Key
GJPICJJJRGTNOD-UHFFFAOYSA-N
SMILES
COC1=C(C=CC=C1)OC2=C(N=C(C3=NC=CC=N3)N=C2NS(=O)(C4=CC=C(C(C)(C)C)C=C4)=O)OCCO
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.16 | 100 | |
| Ethanol | 27.58 | 50 |
Preparing Stock Solutions
for Bosentan
The following data is based on the product molecular weight 551.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.06 mL | 18.13 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gardiner Effects of bos. (Ro 47-0203), an ETA-, ETB-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats. Br.J.Pharmacol. 1994 PMID: 7921608
- Clozel Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J.Pharmacol.Exp.Ther. 1994 PMID: 8035319
Product Specific Notices for Bosentan
For research use only
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