BMS CCR2 22
Tocris Bioscience, part of Bio-Techne | Catalog # 3129
High affinity, potent CCR2 antagonist
Key Product Details
Description
High affinity, potent CCR2 antagonist
Product Description
BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.Product Specifications
Molecular Weight
593.66
Formula
C28H34F3N5O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CAS Number
445479-97-0
PubChem ID
24801690
InChI Key
IBPXYDUJQWENPM-XZOQPEGZSA-N
SMILES
O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.37 | 100 | |
| Ethanol | 5.94 | 10 |
Preparing Stock Solutions
for BMS CCR2 22
The following data is based on the product molecular weight 593.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.68 mL | 8.42 mL | 16.84 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.37 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.68 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- You CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 2010 PMID: 19864434
- Cherney Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 2008 PMID: 18232650
Product Specific Notices for BMS CCR2 22
For research use only
Loading...
Loading...