BMS 191011
Tocris Bioscience, part of Bio-Techne | Catalog # 2665
Potent KCa1.1 (BK) channel opener
Key Product Details
Description
Potent KCa1.1 (BK) channel opener
Product Description
BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).Product Specifications
Molecular Weight
370.71
Formula
C16H10ClF3N2O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
CAS Number
202821-81-6
PubChem ID
10474339
InChI Key
QKOWACXSXTXRKA-UHFFFAOYSA-N
SMILES
OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.07 | 100 |
Preparing Stock Solutions
for BMS 191011
The following data is based on the product molecular weight 370.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.70 mL | 13.49 mL | 26.98 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.40 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.70 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hewawasam Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts.
- Romine 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 2007 PMID: 17266205
Product Specific Notices for BMS 191011
For research use only
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