BIX NHE1 inhibitor

Tocris Bioscience, part of Bio-Techne | Catalog # 5512

Potent and selective NHE1 inhibitor
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Key Product Details

Description

Potent and selective NHE1 inhibitor

View all Na+/Ca2+ Exchanger Inhibitors »

Product Description

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Product Specifications

Molecular Weight

392.80

Formula

C16H19F3N4O2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride

CAS Number

1422252-46-7

PubChem ID

121513866

InChI Key

SLSZLEROFKLICF-UHFFFAOYSA-N

SMILES

CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.64 50

Preparing Stock Solutions for BIX NHE1 inhibitor

The following data is based on the product molecular weight 392.80

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.09 mL 25.46 mL 50.92 mL
2.5 mM 1.02 mL 5.09 mL 10.18 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
25 mM 0.10 mL 0.51 mL 1.02 mL

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Product Documents for BIX NHE1 inhibitor

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIX NHE1 inhibitor

For research use only

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