BINA

Tocris Bioscience, part of Bio-Techne | Catalog # 4048

Selective positive allosteric modulator of mGlu2 receptors
Catalog #
Availability
Size / Price
Qty
4048/10
4048/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Selective positive allosteric modulator of mGlu2 receptors

Alternative Names

Biphenyl-indanone A

View all Group II mGluR Modulators »

Product Description

BINA is a selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Product Specifications

Molecular Weight

454.56

Formula

C30H30O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid

CAS Number

866823-73-6

PubChem ID

9868580

InChI Key

KMKBEESNZAPKMP-UHFFFAOYSA-N

SMILES

CC1=C(C)C(C(C(C5CCCC5)C4)=O)=C4C=C1OCC2=CC(C3=CC=C(C(O)=O)C=C3)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.46 100

Preparing Stock Solutions for BINA

The following data is based on the product molecular weight 454.56

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.20 mL 11.00 mL 22.00 mL
5 mM 0.44 mL 2.20 mL 4.40 mL
10 mM 0.22 mL 1.10 mL 2.20 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for BINA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BINA

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.