BIMU 8

Name: BIMU 8
Brand: Tocris Bioscience
SKU: 4374

Tocris Bioscience, part of Bio-Techne | Catalog # 4374

Citations (16)

COA / SDS

Potent 5-HT4 agonist

Key Product Details

Description:	Potent 5-HT₄ agonist
Chemical Name:	2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	378.9

View Full Technical Details for BIMU 8

Technical Data
Citations

Biological Activity for BIMU 8

BIMU 8 is a potent 5-HT₄ receptor full agonist (K_D = 77 nM and EC₅₀ = 18 nM for wild type 5-HT₄ receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.

Compound Libraries for BIMU 8

BIMU 8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BIMU 8

M. Wt	378.9
Formula	C₁₉H₂₆N₄O₂.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	134296-40-5
PubChem ID	5311028
InChi Key	NQYXXIUVFVOJCX-XZPOUAKSSA-N
Smiles	[H][C@]12CC[C@](CC(NC(N3C(C=CC=C4)=C4N(C(C)C)C3=O)=O)C2)([H])N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIMU 8

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.42	75
	DMSO	37.89	100

Preparing Stock Solutions for BIMU 8

The following data is based on the product molecular weight 378.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.20 mL	26.39 mL
5 mM	0.53 mL	2.64 mL	5.28 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for BIMU 8

References are publications that support the biological activity of the product.

Schaus Synthesis and structure-activity relationships of potent and orally active 5-HT₄ receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 1998 PMID: 9599243
Pellissier Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 2009 PMID: 19168624