BGP 15

Product Description

BGP 15 is a PARP inhibitor (IC₅₀ = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. BGP 15 also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Solubility

Preparing Stock Solutions for BGP 15

The following data is based on the product molecular weight 351.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.47 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chung HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 2008 PMID: 18223156
• Ohlen BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 2017 PMID: 28439028
• Racz BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 2002 PMID: 11931842
• Henstridge Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 2014 PMID: 24430435
• Szabados BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 2000 PMID: 10692558