BGC 20-761
Tocris Bioscience, part of Bio-Techne | Catalog # 3326
High affinity 5-HT6 antagonist
Key Product Details
Description
High affinity 5-HT6 antagonist
Product Description
BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.Product Specifications
Molecular Weight
294.39
Formula
C19H22N2O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
CAS Number
17375-63-2
PubChem ID
6918515
InChI Key
VSGPGYWZVPDDSK-UHFFFAOYSA-N
SMILES
CN(CCC2=C(C3=CC=CC=C3)NC1=CC=C(OC)C=C12)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.44 | 100 | |
| Ethanol | 14.72 | 50 |
Preparing Stock Solutions
for BGC 20-761
The following data is based on the product molecular weight 294.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.40 mL | 16.98 mL | 33.97 mL |
| 5 mM | 0.68 mL | 3.40 mL | 6.79 mL |
| 10 mM | 0.34 mL | 1.70 mL | 3.40 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mitchell BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 2006 PMID: 16298400
- Glennon 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 2000 PMID: 10715164
Product Specific Notices for BGC 20-761
For research use only
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