Betulinic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 3906

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
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Key Product Details

Description

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

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Product Description

Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC50 = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.

Product Specifications

Molecular Weight

456.70

Formula

C30H48O3

Storage

Store at +4°C

Chemical Name

(+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid

CAS Number

472-15-1

PubChem ID

64971

InChI Key

QGJZLNKBHJESQX-FZFNOLFKSA-N

SMILES

O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@@]([H])2CC[C@@]4([H])[C@](C)3CC[C@]5([C@](O)=O)[C@@]([H])4[C@H]([C@@](C)=C)CC5)([H])C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.84 50

Preparing Stock Solutions for Betulinic acid

The following data is based on the product molecular weight 456.70

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.38 mL 21.90 mL 43.79 mL
2.5 mM 0.88 mL 4.38 mL 8.76 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Betulinic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Betulinic acid

For research use only

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