β-Estradiol
Tocris Bioscience, part of Bio-Techne | Catalog # 2824
Endogenous ER agonist
Key Product Details
Description
Endogenous ER agonist
Alternative Names
17 β-Estradiol
Product Description
β-Estradiol is an endogenous estrogen receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.α-Estradiol also available.
Product Specifications
Molecular Weight
272.38
Formula
C18H24O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(17β)-Estra-1,3,5(10)-triene-3,17-diol
CAS Number
50-28-2
PubChem ID
5757
InChI Key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES
[H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.24 | 100 | |
| Ethanol | 20.43 | 75 with gentle warming |
Preparing Stock Solutions
for β-Estradiol
The following data is based on the product molecular weight 272.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.67 mL | 18.36 mL | 36.71 mL |
| 5 mM | 0.73 mL | 3.67 mL | 7.34 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.67 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thomas Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005 PMID: 15539556
- Kuiper Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 1997 PMID: 9048584
Product Specific Notices for β-Estradiol
For research use only
⚠ WARNING: This product can expose you to chemicals including Estradiol 17B, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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