Bestatin

Name: Bestatin
Brand: Tocris Bioscience
SKU: 1956
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1956

(1)

Citations (19)

COA / SDS

Aminopeptidase inhibitor

Key Product Details

Description:	Aminopeptidase inhibitor
Alternative Names:	Ubenimex
Chemical Name:	N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
Purity:	≥98% (HPLC)
Molecular Weight:	308.38

View Full Technical Details for Bestatin

Technical Data
Citations / Reviews (1)

Biological Activity for Bestatin

Bestatin is an aminopeptidase inhibitor (K_i = 0.001 - 90 mM); inhibits enkephalin metabolism and leukotriene A₄ hydrolase. Inhibits tumor cell proliferation.

Technical Data for Bestatin

M. Wt	308.38
Formula	C₁₆H₂₄N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	58970-76-6
PubChem ID	72172
InChi Key	VGGGPCQERPFHOB-RDBSUJKOSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bestatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	3.08	10

Preparing Stock Solutions for Bestatin

The following data is based on the product molecular weight 308.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.43 mL	162.14 mL	324.28 mL
0.5 mM	6.49 mL	32.43 mL	64.86 mL
1 mM	3.24 mL	16.21 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL

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Reconstitution Calculator

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References for Bestatin

References are publications that support the biological activity of the product.

Scornik and Botbol Bestatin as an experimental tool in mammals. Curr.Drug Metab. 2001 PMID: 11465152
Umezawa Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 1976 PMID: 931798
Imamura and Kimura Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma 2000 PMID: 11042531