Bestatin is an aminopeptidase inhibitor (K_i = 0.001 - 90 mM); inhibits enkephalin metabolism and leukotriene A₄ hydrolase. Inhibits tumor cell proliferation.

Product Specifications

Molecular Weight

308.38

Formula

C₁₆H₂₄N₂O₄

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine

CAS Number

58970-76-6

PubChem ID

72172

InChI Key

VGGGPCQERPFHOB-RDBSUJKOSA-N

SMILES

CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	3.08	10

Preparing Stock Solutions for Bestatin

The following data is based on the product molecular weight 308.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.43 mL	162.14 mL	324.28 mL
0.5 mM	6.49 mL	32.43 mL	64.86 mL
1 mM	3.24 mL	16.21 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Scornik and Botbol Bestatin as an experimental tool in mammals. Curr.Drug Metab. 2001 PMID: 11465152
Umezawa Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 1976 PMID: 931798
Imamura and Kimura Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma 2000 PMID: 11042531

Bestatin

Tocris Bioscience, part of Bio-Techne | Catalog # 1956

Key Product Details

Description

Alternative Names

View all Aminopeptidase Inhibitors »

Product Description