Beraprost sodium
Tocris Bioscience, part of Bio-Techne | Catalog # 4180
Potent prostacyclin IP receptor agonist
Discontinued Product
4180 has been discontinued.
View all Prostanoid Receptor Agonists products.
Key Product Details
Description
Potent prostacyclin IP receptor agonist
Product Description
Beraprost sodium is a potent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.Product Specifications
Molecular Weight
420.47
Formula
C24H29NaO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
rel-(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-1-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl)-1H-cyclopenta[b]benzofuran-5-butanoic acid sodium salt
CAS Number
496807-11-5
PubChem ID
23663404
InChI Key
JLHRLDZCMGGIKW-OQNJEIHKSA-M
SMILES
O[C@@H]1C[C@H]2[C@H](C(C=CC=C3CCCC(O[Na])=O)=C3O2)[C@H]1/C=C/[C@@H](O)C(C)CC#CC.O[C@H]4C[C@@H]5[C@@H](C(C=CC=C6CCCC(O[Na])=O)=C6O5)[C@@H]4/C=C/[C@H](O)C(C)CC#CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.51 | 25 |
Preparing Stock Solutions
for Beraprost sodium
The following data is based on the product molecular weight 420.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.51 mL | 47.57 mL | 95.13 mL |
| 1.25 mM | 1.90 mL | 9.51 mL | 19.03 mL |
| 2.5 mM | 0.95 mL | 4.76 mL | 9.51 mL |
| 12.5 mM | 0.19 mL | 0.95 mL | 1.90 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Saito Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 1995 PMID: 7609334
- Miyamoto Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 2003 PMID: 14504133
Product Specific Notices for Beraprost sodium
For research use only
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