Benidipine hydrochloride

Name: Benidipine hydrochloride
Brand: Tocris Bioscience
SKU: 3934

Tocris Bioscience, part of Bio-Techne | Catalog # 3934

Citations (6)

COA / SDS

Non-selective Cav blocker; also mineralocorticoid receptor antagonist

Discontinued Product

3934 has been discontinued. View all Non-selective Cav Blockers products.

Key Product Details

Description:	Non-selective Ca_v blocker; also mineralocorticoid receptor antagonist
Alternative Names:	KW 3049
Chemical Name:	(4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	542.02

View Full Technical Details for Benidipine hydrochloride

Technical Data
Citations

Biological Activity for Benidipine hydrochloride

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca²⁺ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Technical Data for Benidipine hydrochloride

M. Wt	542.02
Formula	C₂₈H₃₁N₃O₆.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	91599-74-5
PubChem ID	76968919
InChi Key	SPMJXDRNJQIBTB-IMEZZWDRSA-N
Smiles	CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Benidipine hydrochloride

References are publications that support the biological activity of the product.

Kosaka The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 2010 PMID: 20307534
Yao Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 2006 PMID: 16565579

Benidipine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3934

Key Product Details

Biological Activity for Benidipine hydrochloride

Technical Data for Benidipine hydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Benidipine hydrochloride

Product Documents for Benidipine hydrochloride

COA

Certificate of Analysis

SDS

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