BDPIC New
Tocris Bioscience, part of Bio-Techne | Catalog # 9024
BromoTag®-dTAG proximity inducing chimera
Key Product Details
Description
BromoTag®-dTAG proximity inducing chimera
Alternative Names
BromoTag®-dTAG proximity inducing chimera
Product Description
BDPIC (BromoTag®-dTAG proximity inducing chimera) is a non-covalent, bifunctional molecule inducing proximity between BromoTag- and dTAG-fused proteins. Comprises BromoTag® Ligand and dTAG Ligand, connected by a PEG linker. Can be used in targeted dephosphorylation of phosphoproteins, where phosphatases, tagged with BromoTag, are directed to phospho-SMAD3, tagged with dTAG. Also used for targeted dephosphorylation of TFEB-dTAG through induced proximity to BromoTag-PPP2CA.BromoTag® is a registered trademark of the University of Dundee and is used under license.
Licensing Information
Sold under licence from the University of DundeeProduct Specifications
Molecular Weight
1279.94
Formula
C67H83ClN6O15S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-1-(2-(((R)-17-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,16-dioxo-6,9,12,15-tetraoxa-3-azanonadecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
InChI Key
RXBCLTAXVTWIHO-LARGNDFUSA-N
SMILES
ClC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(C)S4)C)[C@@H](CC)C(OCCOCCOCCOCCNC(COC(C=CC=C5)=C5[C@@H](CCC6=CC(OC)=C(OC)C=C6)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 127.99 | 100 |
Preparing Stock Solutions
for BDPIC
The following data is based on the product molecular weight 1279.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.78 mL | 3.91 mL | 7.81 mL |
| 5 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 10 mM | 0.08 mL | 0.39 mL | 0.78 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brewer Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling. iScience 2024 PMID: 39104417
- Zhao Targeted dephosphorylation of TFEB promotes its nuclear translocation. iScience 2024 PMID: 39081292
Product Specific Notices for BDPIC
For research use only
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