BCH

Name: BCH
Brand: Tocris Bioscience
SKU: 5027

Tocris Bioscience, part of Bio-Techne | Catalog # 5027

Citations (6)

COA / SDS

LAT1 inhibitor

Key Product Details

Description:	LAT1 inhibitor
Chemical Name:	2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
Molecular Weight:	155.2

View Full Technical Details for BCH

Technical Data
Citations

Biological Activity for BCH

BCH is an inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.

Technical Data for BCH

M. Wt	155.2
Formula	C₈H₁₃NO₂
Storage	Store at RT
CAS Number	20448-79-7
PubChem ID	115288
InChi Key	MPUVBVXDFRDIPT-UHFFFAOYSA-N
Smiles	NC1(C(O)=O)CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BCH

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.52	100

Preparing Stock Solutions for BCH

The following data is based on the product molecular weight 155.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.44 mL	32.22 mL	64.43 mL
5 mM	1.29 mL	6.44 mL	12.89 mL
10 mM	0.64 mL	3.22 mL	6.44 mL
50 mM	0.13 mL	0.64 mL	1.29 mL

Molarity Calculator

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Reconstitution Calculator

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References for BCH

References are publications that support the biological activity of the product.

Lin L-type amino acid transporter-1 overexpression and melp. sensitivity in Barrett's adenocarcinoma. Neoplasia 2004 PMID: 15068672
Fraga L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 2002 PMID: 11925469
Kim BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 2008 PMID: 18520037

BCH