BC 11 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 4372
Selective urokinase (uPA) inhibitor
Product Description
BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.Product Specifications
Molecular Weight
290.97
Formula
C8H11BN2O2S.HBr
Storage
Store at -20°C
Chemical Name
Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
CAS Number
443776-49-6
PubChem ID
78243712
InChI Key
PAFZAMOVHIRQOD-UHFFFAOYSA-N
SMILES
NC(SCC1=CC=C(B(O)O)C=C1)=N.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.82 | 20 with gentle warming | |
| DMSO | 29.1 | 100 |
Preparing Stock Solutions
for BC 11 hydrobromide
The following data is based on the product molecular weight 290.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.44 mL | 17.18 mL | 34.37 mL |
| 5 mM | 0.69 mL | 3.44 mL | 6.87 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Longo Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 2015 PMID: 26029857
- Smith Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract)
Product Specific Notices for BC 11 hydrobromide
For research use only
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