BAY 805
Tocris Bioscience, part of Bio-Techne | Catalog # 7984
Potent and selective inhibitor of USP21; also NF-κB activator
Key Product Details
Description
Potent and selective inhibitor of USP21; also NF-κB activator
Product Description
BAY 805 is a potent and selective inhibitor of USP21 (IC50 = 6 nM, Kd = 2.2 nM). BAY 805 induces NF-κB activation (EC50= 17 nM in a cell-based reporter assay).Product Specifications
Molecular Weight
507.58
Formula
C24H28F3N5O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide
CAS Number
2925481-88-3
PubChem ID
167312463
InChI Key
LXRBPWHQMGKMRT-GOSISDBHSA-N
SMILES
N#CC(C=C1)=CC=C1CC2=NN=C(S2)NC([C@@H](CC(C)C)NC(C3(CCCCC3)C(F)(F)F)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.76 | 100 | |
| Ethanol | 50.76 | 100 |
Preparing Stock Solutions
for BAY 805
The following data is based on the product molecular weight 507.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.85 mL | 19.70 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Göricke Discovery and characterization of BAY-805, a potent and selective inhibitor of ubiquitin-specific protease USP21. J.Med.Chem 2023 PMID: 36802665
Product Specific Notices for BAY 805
For research use only
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