BAY 707

Name: BAY 707
Brand: Tocris Bioscience
SKU: 6562

Tocris Bioscience, part of Bio-Techne | Catalog # 6562

COA / SDS

Potent and selective MTH1 inhibitor

Key Product Details

Description:	Potent and selective MTH1 inhibitor
Chemical Name:	N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	288.34

View Full Technical Details for BAY 707

Technical Data
Citations

Biological Activity for BAY 707

BAY 707 is a potent and selective MTH1 inhibitor (IC₅₀ = 2.3 nM); exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. BAY 707 is cell-permeable and active in vivo, and displays no antitumor activity in vitro or in vivo.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-707 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 707 is reviewed on the chemical probes website.

Technical Data for BAY 707

M. Wt	288.34
Formula	C₁₅H₂₀N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2109805-96-9
PubChem ID	129012086
InChi Key	RPMGXDCRCWWCRY-JTQLQIEISA-N
Smiles	CCNC(C1=CC2=C(N3CCOC[C@@H]3C)C=CN=C2N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 707

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.83	100
	ethanol	2.88	10

Preparing Stock Solutions for BAY 707

The following data is based on the product molecular weight 288.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.68 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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Reconstitution Calculator

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References for BAY 707

References are publications that support the biological activity of the product.

Ellermann Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target. ACS Chem.Biol. 2017 PMID: 28679043
Rahm Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design. J.Med.Chem. 2018 PMID: 29485874