Bay 11-7085

Name: Bay 11-7085
Brand: Tocris Bioscience
SKU: 1743

Tocris Bioscience, part of Bio-Techne | Catalog # 1743

Citations (33)

COA / SDS

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Alternative Names

Bay 11-7083

View all NFkB/IkB Inhibitors »

Product Description

Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC₅₀ ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Product Specifications

Molecular Weight

249.33

Formula

C₁₃H₁₅NO₂S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

CAS Number

196309-76-9

PubChem ID

5353432

InChI Key

VHKZGNPOHPFPER-ONNFQVAWSA-N

SMILES

CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.93	100
	Ethanol	24.93	100

Preparing Stock Solutions for Bay 11-7085

The following data is based on the product molecular weight 249.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Pierce Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 1997 PMID: 9261113
Scaife Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 2002 PMID: 12460901
Hu An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 2001 PMID: 11507084